F8

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Three novel F8 mutations in sporadic haemophilia A cases

Hemophilia A (HA) is an X-linked hereditary disorder characterized by bleeding of variable severity through mild, moderate to severe owing to large range of mutations in the Factor VIII (F8) gene (Bowen 2002). All kind of F8 mutations, except repeats, have been reported for HA, in total up to 2370 (Human Genome Mutation Database 2005). A preliminary study was conducted in our lab for identifica...

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The field F8 as a Boolean manifold

In a previous paper (“Hexagonal Logic of the Field F8 as a Boolean Logic with Three Involutive Modalities”, in The road to Universal Logic), we proved that elements of P(8), i.e. functions of all finite arities on the Galois field F8, are compositions of logical functions of a given Boolean structure, plus three geometrical cross product operations. Here we prove that P(8) admits a purely logic...

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F8 genetic analysis strategies when standard approaches fail.

Haemophilia A is a common X-linked recessive disorder caused by mutations in F8 leading to deficiency or dysfunction of coagulant factor VIII (FVIII). Despite tremendous improvements in mutation screening methods, in a small group of patients with FVIII deficiency suffering from haemophilia A, no DNA change can be found. In these patients, analysis reveals no causal mutations even after sequenc...

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Provable Security of KASUMI and 3GPP Encryption Mode f8

Within the security architecture of the 3GPP system there is a standardised encryption mode f8 based on the block cipher KASUMI. In this work we examine the pseudorandomness of the block cipher KASUMI and the provable security of f8. First we show that the three round KASUMI is not a pseudorandom permutation ensemble but the four round KASUMI is a pseudorandom permutation ensemble under the ada...

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Characterisation and quantification of F8 transcripts of ten putative splice site mutations.

Mutations affecting splice sites comprise approximately 7.5 % of the known F8 gene mutations but only a few were verified at mRNA level. In the present study, 10 putative splice site mutations were characterised by mRNA analysis using reverse transcription PCR (RT-PCR). Quantitative real-time RT-PCR (RT-qPCR) and co-amplification fluorescent PCR were used in combination to quantify the amount o...

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ژورنال

عنوان ژورنال: Arthropod Management Tests

سال: 2012

ISSN: 2155-9856

DOI: 10.4182/amt.2012.f8